Products
Isophthaloyl Chloride
Another name：Isophthaloyl dichloride； 1,3-Benzenedicarbonyl dichloride； IPC;
CasNo: 99-63-8 Purity： ≥99.9% Molecular Structure： C8H4Cl2O2
Isophthaloyl Chloride Basic Product Information
| Product Name | Isophthaloyl Chloride | CAS | 99-63-8 |
| Synonyms | Isophthaloyl dichloride； 1,3-Benzenedicarbonyl dichloride； IPC; |
Molecular Formula | C8H4Cl2O2 |
| EINECS Number | 202-774-7 | Molecular Structure | |
| Appearance | White crystalline solid |
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| Purity | ≥99.9% | ||
| Supply Ability | 830T Per Month | ||
Isophthaloyl Chloride Appearance/Package/Shipping/Storage
Package
ISO Tanker
Storage condition
2-8℃, avoid light, stay away from fire and heat sources.
Isophthaloyl Chloride Application
Our high quality ICL can be used as monomer in a variety of high performance polymers and fibers, where it is valued for flame resistance, temperature stability, chemical resistance, and
flexibility. In addition, ICL is also used in the production of pesticides and medication as well as
worked as an effective stabilizer, and used to stabilize isocyanates and urethane prepolymers.
1,3-Benzenedicarbonyl chloride literature
G4 Sensing Pyridyl-Thiazole Polyamide Represses c-KIT Expression in Leukemia Cells
Paul, Raj,Dutta, Debasish,Das, Tania,Debnath, Manish,Dash, Jyotirmayee
, p. 8590 - 8599 (2021)
Specific sensing and functional tuning of nucleic acid secondary structures remain less explored to date. Herein, we report a thiazole polyamide TPW that binds specifically to c-KIT1 G-quadruplex (G4) with sub-micromolar affinity and ～1 : 1 stoichiometry and represses c-KIT proto-oncogene expression. TPW shows up to 10-fold increase in fluorescence upon binding with c-KIT1 G4, but shows weak or no quantifiable binding to other G4s and ds26 DNA. TPW can increase the number of G4-specific antibody (BG4) foci and mark G4 structures in cancer cells. Cell-based assays reveal that TPW can efficiently repress c-KIT expression in leukemia cells via a G4-dependent process. Thus, the polyamide can serve as a promising probe for G-quadruplex recognition with the ability to specifically alter c-KIT oncogene expression.
Anion binding and fluoride ion induced conformational changes in bisurea receptors
Shu, Xi,Fan, Yu,Li, Shoujian,Jin, Yongdong,Xia, Chuanqin,Huang, Chao
, p. 2033 - 2045 (2020)
Two types of bisurea receptors, containing either 2,6-substituted phenyl or 2,6-substituted pyridine, are prepared, and their anion binding properties are investigated. Compared with the phenyl bisurea receptors, the pyridine bisurea receptors can be more easily converted to a cis-cis conformation from a trans-trans conformation, providing a cavity that more closely matches the volume of a fluoride ion and increasing the number of NH sites bound to the fluoride ion. As a result, the pyridine bisurea in cis-cis conformation shows stronger affinity and higher selectivity to fluoride ions, which is supported by crystal structure analysis and NMR titration experiments. Through DFT calculations, a mechanism of fluoride ion induced conformational changes of pyridine bisurea receptors is proposed, and the energy barriers of conformational changes for both types of receptors are determined.
Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids
Yu, Zhiqun,Yao, Hongmiao,Xu, Qilin,Liu, Jiming,Le, Xingmao,Ren, Minna
supporting information, p. 685 - 689 (2021/04/09)
The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.
Method for increasing reaction speed of isophthaloyl dichloride
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Paragraph 0019-0033, (2020/05/01)
The invention belongs to the technical field of organic synthesis, and particularly relates to a method for increasing the reaction speed of isophthaloyl dichloride. The method comprises the followingsteps: adding acetonitrile into thionyl chloride, adding a mixture of thionyl chloride and acetonitrile, isophthalic acid and a catalyst into a reaction kettle, carrying out a reflux reaction, and carrying out after-treatment after the reaction is finished, thereby obtaining isophthaloyl dichloride. Compared with a traditional thionyl chloride method, acetonitrile is added as an auxiliary catalyst, so the reaction activity of isophthalic acid is improved, reaction time is greatly shortened by 30%, and yield is increased; and the purity of the produced isophthaloyl dichloride reaches 99.92% orabove, and the yield is greater than 99%.
Synthesis, antimicrobial activity, and ion transportation investigation of four new [1 + 1] condensed furan and thiophene-based cycloheterophane amides
?zcan, Hafize,Erku?, Betül,Zaim, ?mer
, (2020/02/18)
Four new macrocyclic compounds with thiophene (L1 and L2) and furan (L3 and L4) rings were synthesized and characterized by IR, 1H NMR, 13C NMR, and Q-TOF spectral data. Macrocyclic amides (L1, L2, L3, and L4) were tested for ion transportation with Na+ and K+ ions, and also, antimicrobial activities were investigated against the Gram-negative Escherichia coli ATCC 25922, Gram-positive Staphylococcus aureus ATCC 25923, Gram-negative Listeria monocytogenes ATCC 19115, Gram-negative Salmonella typhimurium ATCC 14028, Bacillus cereus bacteria, and Candida albicans ATCC 10231 for all amides.
1,3-Benzenedicarbonyl chloride Upstream and downstream
99-63-8 Upstream product
121-91-5
isophthalic acid
1459-93-4
dimethyl Isophthalate
881-99-2
1,3-bis-trichloromethyl-benzene
75-36-5
acetyl chloride
64-17-5
ethanol
7719-09-7
thionyl chloride
10026-13-8
phosphorus pentachloride
814-29-9
Tributylphosphine oxide
99-63-8 Downstream Products
74048-19-4
1,3-bis(diazoacetyl)benzene
70584-06-4
1,3-bis(3,5-dimethylpyrazolyl-1-carbonyl)benzene
6370-78-1
N,N'-bis-(5-benzoylamino-9,10-dioxo-9,10-dihydro-[1]anthryl)-isophthalamide
15517-45-0
1,4-phenylenebis[(4-methoxypheny)lmethanone]
7477-29-4
1,3-phenylenebis[(4-methoxyphenyl)methanone]
5436-05-5
1, 3-phenylenebis ((4-hydroxyphenyl)methanone)
14334-36-2
N,N,N',N'-tetramethyl-1,3-benzenedicarboxamide
13698-87-8
N1,N1,N3,N3-tetraethylisophthalamide
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