2-AMINO-5-METHYLHEXANE Basic Product Information

Product Name	2-AMINO-5-METHYLHEXANE	CAS	28292-43-5
Synonyms	Pentylamine,1,4-dimethyl- (8CI);1,4-Dimethylpentylamine;5-Methyl-2-hexylamine;NSC 73708;dl-2-Amino-5-methylhexane;	Molecular Formula	C7H17N
EINECS Number	248-941-8	Molecular Structure
Appearance	Light Yellow Powder
Purity	99.00%
Supply Ability

2-AMINO-5-METHYLHEXANE Quality documents

2-AMINO-5-METHYLHEXANE Appearance/Package/Shipping/Storage

package

storage condition

Store in cool & dry place,Keep away from strong light and heat

2-AMINO-5-METHYLHEXANE Application

2-AMINO-5-METHYLHEXANE literature

Biochemical and Structural Characterization of an (R)-Selective Transaminase in the Asymmetric Synthesis of Chiral Hydroxy Amines

Li, Fulong,Liang, Youxiang,Wei, Yuwen,Zheng, Yukun,Du, Yan,Yu, Huimin

, p. 4582 - 4589 (2021/08/07)

An (R)-selective transaminase RbTA with excellent stereoselectivity (>99% ee) in the asymmetric amination of hydroxy ketones was identified. Biochemical characterization showed that RbTA exhibited the highest activity toward 4-hydroxy-2-butanone among reported enzymes, and that it has broad substrate specificity, including for aliphatic, aromatic, and alicyclic ketones. Crystallization of RbTA were performed, as were molecular docking and mutagenesis studies. Residue Tyr125 plays a key role in substrate recognition by forming a hydrogen bond with hydroxy ketone. The applicability of the enzyme was determined in preparative-scale synthesis of (R)-3-amino-1-butanol, demonstrating the potential of RbTA as a green biocatalyst for production of value-added chiral hydroxy amines. This study provides an efficient tool for enzymatic synthesis of chiral hydroxy amines, as well as structural insight into substrate recognition by transaminases in the asymmetric amination of hydroxy ketones. (Figure presented.).

Importance of the lipophilic group in carbamates having histamine H₃- receptor antagonist activity

Kiec-Kononowicz,Wiecek,Sasse,Ligneau,Elz,Ganellin,Schwartz,Stark,Schunack

, p. 349 - 355 (2007/10/03)

In order to evaluate changes in the lipophilic part of designed carbamates concerning their potential histamine H₃-receptor antagonist properties a new series of O-[3-(1H-imidazol-4-yl)propanol]carbamates was derived containing N-mono- or dialkenyl, alkynyl, cycloalkyl, or double- branched alkyl substituents. The compounds were tested in vitro for their H₃-receptor antagonist activity on synaptosomes of rat cerebral cortex and shared moderate to high antagonist activity in vitro. In this series 3-(1H- imidazol-4-yl)propyl N-(4-pentenyl)carbamate (4) was the most potent compound in vitro (K(i) = 6.3 nM). H₃-receptor antagonist activity in the central nervous system (CNS) was detected for most compounds in the in vivo H₃- receptor assay based upon measurement of brain N(τ)-methylhistamine levels after p.o. administration to mice. The most effective carbamate in vivo, 3- (1H-imidazol-4-yl)propyl N-(allyl)carbamate (3), showed higher CNS potency (ED₅₀ = 0.48 mg/kg p.o.) than the reference antagonist thioperamide. For some novel carbamates their histamine H₁- and H₂-receptor activities were determined on isolated organs of guinea-pig thereby demonstrating their high H₃-receptor selectivity.

2-AMINO-5-METHYLHEXANE Upstream and downstream

28292-43-5 Upstream product

• 60372-16-9

  bis-(1,4-dimethyl-pentylidene)-hydrazine 

• 110-12-3

  5-Methyl-2-hexanone 

• 627-59-8

  5-methylhexan-2-ol 

• 646-07-1

  4-Methylpentanoic acid 

28292-43-5 Downstream Products

• 40318-40-9

  (3,4-Dimethyl-2,6-dinitro-phenyl)-(1,4-dimethyl-pentyl)-amine 

• 248930-74-7

  (2RS,3R)-3-amino-4-cyclohexyl-N-(1,4-dimethylpentyl)-2-hydroxybutanamide Hydrochloride 

• 1350887-83-0

  5-(1,4-dimethylpentylamino)-3-methyl-1,2-benzoquinone 

• 110-12-3

  5-Methyl-2-hexanone 

• 27298-98-2

  (S)-1-(4-methylphenyl)ethylamine 

• 586-70-9

  (R)-4'-methyl-1-phenylethylamine 

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