3,4,5-Trifluorophenol Basic Product Information

Product Name	3,4,5-Trifluorophenol	CAS	99627-05-1
Synonyms	TFBOH;3,4,5-Trifluoro phenol;2-Fluoro-4-bromophenol;	Molecular Formula	C6H3F3O
EINECS Number	436-160-7	Molecular Structure
Appearance	Light Yellow Powder
Purity	98.00%
Supply Ability

3,4,5-Trifluorophenol Quality documents

3,4,5-Trifluorophenol Appearance/Package/Shipping/Storage

package

storage condition

Store in cool & dry place,Keep away from strong light and heat

3,4,5-Trifluorophenol Application

3,4,5-Trifluorophenol literature

Improved synthesis technology of 3,4,5-trifluorophenol

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Paragraph 0041-0043, (2020/04/29)

The invention discloses a synthesis technology of 3,4,5-trifluorophenol, and belongs to the technical field of organic synthesis. The method comprises the following steps: 3,4,5-trifluorobromobenzeneused as a raw material is lithiated by using n-butyllithium under an ultralow temperature condition, and then reacts with boric acid ester, an alkali is added for quenching to obtain 3,4,5-trifluorophenylborate, the 3,4,5-trifluorophenylborate is oxidized in the presence of hydrogen peroxide, and then undergoes acidolysis to obtain 3,4,5-trifluorophenol, and the obtained 3,4,5-trifluorophenol is simply distilled to obtain the product having a purity reaching 99.9% or above, having a defluorination matter content of below 50 ppm and meeting the requirements of electronic products. The technology adopting lithiation/boronation and the oxidation reaction in a water system has the advantages of mild reaction conditions, few defluorination byproducts, high product purity, and easiness in realization of industrial production.

A practical method for preparation of phenols from arylboronic acids catalyzed by iodopovidone in aqueous medium

Dong, Bin,Ke, Yanxiong,Lu, Guangying,Ren, Jiangmeng,Ren, Yaoyao,Zeng, Bu-Bing,Zhou, Bin

, (2019/09/06)

A novel and efficient strategy for the ipso-hydroxylation of arylboronic acids to phenols has been developed using inexpensive, readily available, air-stable water-soluble povidone iodine as catalyst and aqueous hydrogen peroxide as oxidizing agent. The reactions were performed at room temperature under metal-, ligand- and base-free condition in a short reaction time. The corresponding substituted phenols were obtained in moderate to good yields by oxidative hydroxylation of arylboronic acids in aqueous medium.

Synthesis method of 3, 4, 5-trifluorophenol

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Paragraph 0038-0061, (2019/03/28)

The invention discloses a synthesis method of 3, 4, 5-trifluorophenol. The synthesis method includes following steps: taking 3, 4, 5-trifluorobromobenzene as a raw material, adding a certain volume ofammonia water and cuprous complexing catalyst, allowing

Preparation method of fluorine-containing phenol

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, (2017/08/29)

The invention provides a preparation method of fluorine-containing phenol. The preparation method comprises the following steps of: a) mixing a copper catalyst, a ligand, alkali, fluorine-containing bromobenzene and tertiary butanol for esterification reaction to obtain fluorine-containing phenyl tertiary butyl ester; and b) mixing the fluorine-containing phenyl tertiary butyl ester obtained in the step a) with concentrated sulfuric acid and water for hydrolysis reaction to obtain the fluorine-containing phenol. Compared with the prior art, the preparation method provided by the invention directly prepares a fluorine-containing phenyl tertiary butyl ester intermediate by adopting tertiary butanol in a breakthrough manner, and then prepares the fluorine-containing phenol through the hydrolysis reaction. The process route is simple and can be continuously operated, the reaction condition is mild, and the conventional cost of raw materials is low, and the method is suitable for industrial production; moreover, the total yield of the fluorine-containing phenol prepared by the preparation method provided by the invention can reach 76% above, and the product purity is 99% above.

3,4,5-Trifluorophenol Upstream and downstream

99627-05-1 Upstream product

• 143418-49-9

  3,4,5-trifluorophenylboronic acid 

• 156006-28-9

  3,4,5-trifluorophenylmagnesium bromide 

• 138526-69-9

  3,4,5-trifluoro-1-bromobenzene 

• 163733-96-8

  3,4,5-trifluoro aniline 

• 121-43-7

  Trimethyl borate 

• 150-46-9

  triethyl borate 

• 5419-55-6

  Triisopropyl borate 

• 688-74-4

  boric acid tributyl ester 

99627-05-1 Downstream Products

• 1131543-24-2

  (5,10,15,20-tetramesitylporphyrinato)Fe(3,4,5-trifluorophenolato) 

• 1052241-41-4

  4-[difluoro(3,4,5-trifluorophenoxy)methyl]-4'''-n-pentyl-2',2'',3,5-tetrafluoro-1,1',4',1'',4'',1'''-quaterphenyl 

• 1412761-33-1

  trimethyl(2-(3,4,5-trifluorophenoxy)phenyl)silane 

• 1412761-65-9

  trimethyl(2,3,4-trifluoro-6-phenoxyphenyl)silane 

• 1412761-41-1

  4-trifluoromethyl-2-((3,4,5-trifluorophenoxy)phenyl)trimethylsilane 

• 1412761-74-0

  trimethyl(2,3,4-trifluoro-6-(3-trifluoromethylphenoxy)phenyl)silane 

• 1412761-37-5

  (4-methoxy-2-(3,4,5-trifluorophenoxy)phenyl)trimethylsilane 

• 1412761-70-6

  trimethyl(2,3,4-trifluoro-6-(3-methoxyphenoxy)phenyl)silane 

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